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shown in Figure 16-12. The most common is the Sigma-blade (Figure 16-12a), with unequal wings to induce randomness. With tangential blades, additional randomness in introduced by having the blades turning at different speeds. Using acid base titration in a viscous non-Newtonian CMC (carboxymethyl cellulose) solution, the time for complete mixing was determined as a function of blade speed ratio, as shown in Figure 16-13, where equal rotational speeds are shown to take almost twice as long to reach molecular scale mixing as when the blades are turning at different speeds (e.g., a speed ratio > 1.2). For Newtonian and many non-Newtonian mixtures, the time to achieve molecular scale mixing is generally inversely proportional to average blade speed, as shown in Figure 16-14. One of the problems in scale-up is that viscous energy dissipation is usually great with high viscosity uids, yet the surface/volume ratio decreases with increasing size. At the same mixer speed, the torque and dissipation are higher in a high viscosity uid. Scale-up at constant dissipation requires decreasing N as NL /NS = (DS /DL )3/2 , but the area per volume that is available for heat transfer decreases faster, with DS /DL . Consequently, most mixer manufacturers decrease blade speed and power/volume as size is increased, to prevent product degradation. This results in longer mixing times at the large scale.

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This method can be applied to an established explant culture or directly to freshly dissected and dissociated tumor tissue as follows The primary explant technique is used to establish a cell line representative of the original teratocarcinoma There are ethical and safety issues concerned with collection of human biopsy material (see 2)..

The Rectangle tool slot, which appears here as a tearaway, and the tools housed with it allow you to draw many shapes.

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They argued that the symptomatic bene ts were small and con ned to those with mild symptoms and that the effect upon joint space was of unproven clinical usefulness In 8, a large controlled study is described in which large daily chitosan supplements are compared with a placebo After six months the chitosan group had lost an average of a half a kilogram more than the control group Despite this effect being statistically signi cant, the authors regarded it as not clinically signi cant and that it did not warrant the use of chitosan for weight loss Similarly, the chitosan group registered a statistically signi cant but clinically unimportant fall in their circulating low-density lipoprotein cholesterol.

(5.6-8)

for($i=0; $i < count($users); $i++) { for($j=0; $j < 5; $j++) { if($users[$i][$j][ valid ] == false) { // found invalid user, group is compromised // exit both loops break 2; } } }

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Statistical signi cance may also be the product of bias in the design or conduct of the experiment: If the patient or experimenter was able to detect the difference between a real treatment and a placebo If there was poor matching of subjects at the outset of the experiment If there was some systematic bias in the measuring of outcome in the two groups, such as if the two groups were measured by different operators or machines or if they were measured at different times of the day or on different days of the week Animal experiments Experiments with human volunteers are always fraught with dif culties and uncertainties such as:.

Version control applications, which are discussed in the following section, even have the ability to automatically generate a ChangeLog. The advantage to this approach is the developer doesn t have to spend project time editing or updating the log. However, a disadvantage to this is the file becomes less personalized and sometimes makes it harder to fully understand.

You may prefer to use the Microsoft Clip Organizer to access image files. Clip Organizer is essentially a stand-alone version of the Clip Art task pane. To display the Clip Organizer, click the Organize Clips hyperlink at the bottom of the task pane. Figure 22.15 shows the Microsoft Clip Organizer. You can also add new files to the Clip Organizer. You may want to do so if you tend to insert a particular graphic file (such as your company logo) into your worksheets quite often. If you can t find a suitable image, you can go online and browse through the extensive clip art at Microsoft s Clip Gallery Live Web site. Click the Clip Art On Office Online hyperlink (at the bottom of the task pane), and your Web browser will be activated, at which point you can view the images (or listen to the sounds) and add those you want to your Clip Organizer. FIGURE 22.15

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